Endocrine Abstracts

Background: The diagnosis of pheochromocytoma and paraganglioma (PPGL) requires the measurement of plasma metanephrines; however, several pre-analytical parameters can lead to false positive test results. During venipuncture, pain perception may activate the sympathetic nervous system, increasing catecholamine metabolite levels. Furthermore, hypertension patients exhibit sympathetic hyperactivity compared to normotensive subjects. The purpose of this study was to compare the p...

Introduction: Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant disorder from a RET proto-oncogene mutation, characterized by the presence of medullary thyroid carcinoma (MTC), pheochromocytoma and/or primary hyperparathyroidism.Materials and Methods: A retrospective study of 5 probands (3 males and 2 females, age range 31–46 years) and 6 family members (2 males and 4 females, age range 2–50 years) diagnosed as MEN 2A at Ki...